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The calcitonin receptor(CTR) was considered by Lilly to be not worth targeting, it has functions around calcium regulation and bone growth, and the literature is mixed on its effect on weight loss

GLP-1s have helped people in serious need, she said

We adjust dosing based on body weight, insulin response, appetite suppression, and gastric emptying

Research demonstrates that patients using semaglutide for weight management can achieve an average weight loss of 12-15% of their starting body weight over 68 weeks

Now, the 0.5mg study included people with Type 2 Diabetes so that may have been the reason for the difference in the effect